Ashley B Hale Selected Research

Phenylketonurias (Phenylketonuria)

2/2015	Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
1/2013	Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
6/2011	Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
1/2009	Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.

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Ashley B Hale Research Topics

Disease

5	Atherosclerosis 01/2018 - 05/2010
4	Vascular Diseases (Vascular Disease) 03/2015 - 05/2010
4	Phenylketonurias (Phenylketonuria) 02/2015 - 01/2009
3	Inflammation (Inflammations) 01/2018 - 05/2010
2	Aortic Aneurysm (Aneurysm, Aortic) 01/2018 - 03/2015
2	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2017 - 11/2016
1	Infections 12/2018
1	Aneurysm (Aneurysms) 01/2018
1	Abdominal Aortic Aneurysm 01/2018
1	Vascular Remodeling 01/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 11/2016
1	Rupture 03/2015
1	Bradycardia 03/2015
1	Cardiovascular Diseases (Cardiovascular Disease) 06/2014
1	Aortic Dissection 06/2014
1	Mitochondrial Diseases (Mitochondrial Disease) 02/2014
1	Parkinson Disease (Parkinson's Disease) 02/2014
1	Neointima 11/2013
1	Atherosclerotic Plaque (Atheroma) 04/2012
1	Gastroparesis 08/2011
1	Heart Failure 11/2009

Drug/Important Bio-Agent (IBA)

5	sapropterin (tetrahydrobiopterin)FDA Link 12/2018 - 05/2010
5	Angiotensin IIIBA 01/2018 - 04/2012
3	Apolipoproteins E (ApoE)IBA 01/2018 - 05/2010
3	Superoxides (Superoxide)IBA 01/2013 - 01/2009
2	LDL CholesterolIBA 01/2017 - 11/2016
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2015 - 05/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2014 - 04/2012
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 06/2011 - 05/2010
2	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 05/2010 - 01/2009
1	LDL Receptors (LDL Receptor)IBA 01/2017
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2017
1	Chemokine ReceptorsIBA 03/2015
1	ChemokinesIBA 03/2015
1	Levodopa (L Dopa)FDA LinkGeneric 03/2015
1	sepiapterinIBA 02/2015
1	SynucleinsIBA 02/2014
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2013
1	MetalsIBA 11/2013
1	Carmustine (FIVB)FDA Link 01/2013
1	Glutathione Disulfide (GSSG)FDA LinkGeneric 01/2013
1	Proteins (Proteins, Gene)FDA Link 04/2012
1	NADPH Oxidases (NAD(P)H oxidase)IBA 04/2012
1	Glutamate-Cysteine LigaseIBA 08/2011
1	Transcription Factors (Transcription Factor)IBA 08/2011
1	AntioxidantsIBA 08/2011
1	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 06/2011
1	Pharmaceutical PreparationsIBA 05/2010
1	LipidsIBA 05/2010
1	ApolipoproteinsIBA 05/2010
1	Adrenergic Agents (Adrenergic Drugs)IBA 11/2009
1	EnzymesIBA 01/2009
1	2-hydroxyethidiumIBA 01/2009
1	arginine methyl esterIBA 01/2009
1	Doxycycline (Periostat)FDA LinkGeneric 01/2009

Therapy/Procedure

1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2018
1	Drug-Eluting Stents 11/2013
1	Stents 11/2013